![]() ![]() Some criticise vapour phase storage freezers for lack of space, with the lower third of the freezer left unusable due to the need for the liquid nitrogen base. ![]() Rather than being stored directly in the liquid nitrogen, however, vapour phase freezers store samples in the vapour created above. Both designs come with pros and cons due to the differing designs of freezer interior.īoth types of freezer contain liquid phase nitrogen. This is where the benefits and drawbacks of each solution are most obvious. In general, the best choice will depend on your needs and requirements. However, advances in technology soon led to the advent of dry or vapour phase storage, where samples are stored above the LN2 rather than in it.īoth types of sample storage freezer design remain in use today, each with their own pros and cons. Originally, the only option was to submerge the sample containers in liquid phase. For long-term storage of samples below the glass transition point of water (-135☌), the limit at which virtually all biological functions stop, a cryogen like liquid nitrogen is the only solution. Since then, LN2 has been considered the gold standard for cryogenic storage. Liquid nitrogen was first used for cryogenic storage in the 1950s, making it possible to store samples at temperatures down to -196☌. The first is vapour phase storage and the other is storing your samples directly in liquid phase nitrogen itself. When storing biological samples at cryogenic temperatures using liquid nitrogen there are two main options to consider. LC-MS innovation: Improve analytical accuracy Which microbioreactor modules are best for you ![]()
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